Failover Cluster Resource Failed by Heartbeat Issue in Windows Server 2012 R2

Symptom

Event 4201: isatap interface is no longer active.

Event 1135: cluster node was removed from the active failover cluster membership.
.

Resolution

Edit Registry

Location: HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\services\TCPIP6\Parameters
KeyType: DWORD (32-bit)
KeyName: DisabledComponents
KeyValue: FF
Reference Link

Modify Failover Cluster Parameters

Import-module failoverclusters
(get-cluster).SameSubnetThreshold = 10
(get-cluster).CrossSubnetThreshold = 10
(get-cluster).CrossSubnetDelay = 4000
(get-cluster).SameSubnetDelay = 2000 

Verify configurations with get-cluster | fl *subnet*

Disable TCP/IP Features

netsh int tcp set global chimney=disabled
netsh int tcp set global netdma=disabled
netsh int ip set global taskoffload=disabled  

Reference Link